In recent years, the genetic testing and selection of IVF embryos, known as preimplantation genetic testing (PGT), has gained much traction in clinical assisted reproduction for preventing transmission of genetic defects. However, a more recent ethically and morally controversial development in PGT is its possible use in selecting IVF embryos for optimal intelligence quotient (IQ) and other non–disease-related socially desirable traits, such as tallness, fair complexion, athletic ability, and eye and hair colour, based on polygenic risk scores (PRS), in what (...) is referred to as PGT-P. Artificial intelligence (AI) and machine learning–based analysis of big data sets collated from genome sequencing of specific human ethnic populations can be used to estimate an individual embryo’s likelihood of developing such multifactorial traits by analysing the combination of specific genetic variants within its genome. Superficially, this technique appears compliant with Islamic principles and ethics. Because there is no modification of the human genome, there is no tampering with Allah’s creation (taghyīr khalq Allah). Nevertheless, a more critical analysis based on the five maxims of Islamic jurisprudence (qawa'id fiqhiyyah) that are often utilized in discourses on Islamic bioethics, namely qaṣd (intention), yaqın̄ (certainty), ḍarar (injury), ḍarūra (necessity), and `urf (custom), would instead reveal some major ethical and moral flaws of this new medical technology in the selection of non–disease-related socially desirable traits, and its non-compliance with the spirit and essence of Islamic law (shariah). Muslim scholars, jurists, doctors, and biomedical scientists should debate this further and issue a fatwa on this new medical technology platform. (shrink)

The spatial organization of the genome is intimately linked to its biological function, yet our understanding of higher order genomic structure is coarse, fragmented and incomplete. In the nucleus of eukaryotic cells, interphase chromosomes occupy distinct.

In this chapter we extend earlier work (Vinuesa et al., Nat Commun 11, 2020) on the potential of artificial intelligence (AI) to achieve the 17 Sustainable Development Goals (SDGs) proposed by the United Nations (UN) for the 2030 Agenda. The present contribution focuses on three SDGs related to healthy and sustainable societies, i.e., SDG 3 (on good health), SDG 11 (on sustainable cities), and SDG 13 (on climate action). This chapter extends the previous study within those three goals and goes (...) beyond the 2030 targets. These SDGs are selected because they are closely related to the coronavirus disease 19 (COVID-19) pandemic and also to crises like climate change, which constitute important challenges to our society. (shrink)

The construction of theoretical models in biology, situated at the cross-roads of biology, mathematics and computer science, often leads to a tool as final product. Its genesis can be named Infogenesis. The procedure of the resolution of theoretical problems is analyzed on examples of practical purposes taken from plant biology.The first example deals with mineral plant nutrition, explaining a way to go from theoretical ionic balances to the experimental realization of nutritional solutions with macro-element components.

This volume starts where the four-volume work by Johannes Hoffmeister, Briefe von und an Hegel, left off. It consists of excerpts from letters, diaries, memoirs, newspaper and journal articles, etc., much of which has never been published before. What emerges is a conflicting picture of Hegel, the man--from which the reader can take his choice. The comments are from contemporaries: relatives, friends, acquaintances, students, colleagues, admirers, critics, and last, but not least, enemies. The chapters are organized chronologically by city of (...) residence, beginning with Stuttgart, 1770-1788, and covering the periods in Tübingen, Bern, Frankfurt, Jena, Bamberg, Nürnberg, Heidelberg, and Berlin. There is a special chapter on the period immediately following Hegel's death, and a final chapter on After-Effects. The biggest chapter by far is the one on the Berlin period, which spans the longest space of time and also covers the time when Hegel's fame had reached its zenith. All told there are 769 excerpts from the pens of such varied personalities as Karl, Christiane, and Marie Hegel, Hölderlin, Goethe, Schelling, Karl Rosenkranz, Eduard Zeller, Fichte, Schleiermacher, Schiller, Schlegel, Brentano, Savigny, Michelet, Schopenhauer, Victor Cousin, Heine, Feuerbach, Bouterwek, Varnhagen v. Ense, K. F. Zeller, Arnold Ruge, Ranke, Eduard Gans, and many others. This book will undoubtedly figure prominently in future biographies of Hegel. However, it is not only for the Hegel specialist. Those who are interested in that specific period of German culture and those who simply enjoy anecdotal historical commentary will find much of interest and amusement here.--H. B. (shrink)